Lewes
- Country: United States
- State: Delaware
- Population: 3,074 (2016)
- Latitude: 38° 46.5' N (38.77456°)
- Longitude: 75° 8.4' W (-75.13935°)
- Elevation: 4 m/13 ft. above sea level
- Time zone: America/New_York (UTC -05:00); DST observed (UTC -04:00)
- Alternate names: Fort Oplandt, Hoornkill, Lewes Creek, Lewes Town, Lewestown, Lewis, Lewis Town, Lewistown, Swanendael, Swanendale, Swansdak, Swansdale, Whoore Kill, Zwaanendael