De Witt
- Country: United States
- State: Iowa
- Population: 5,233 (2016)
- Latitude: 41° 49.4' N (41.82336°)
- Longitude: 90° 32.3' W (-90.53819°)
- Elevation: 216 m/709 ft. above sea level
- Time zone: America/Chicago (UTC -06:00); DST observed (UTC -05:00)
- Alternate names: DeWitt, Vandenburg, Vanderburg