Jefferson City
- Country: United States
- State: Missouri
- Population: 43,013 (2016)
- Latitude: 38° 34.6' N (38.5767°)
- Longitude: 92° 10.4' W (-92.17352°)
- Elevation: 191 m/627 ft. above sea level
- Time zone: America/Chicago (UTC -06:00); DST observed (UTC -05:00)
- Alternate names: City of Jefferson, Jefferson