Sikeston
- Country: United States
- State: Missouri
- Population: 16,327 (2016)
- Latitude: 36° 52.6' N (36.87672°)
- Longitude: 89° 35.3' W (-89.58786°)
- Elevation: 101 m/330 ft. above sea level
- Time zone: America/Chicago (UTC -06:00); DST observed (UTC -05:00)