Columbus
- Country: United States
- State: Mississippi
- Population: 24,561 (2016)
- Latitude: 33° 29.7' N (33.49567°)
- Longitude: 88° 25.6' W (-88.42726°)
- Elevation: 65 m/213 ft. above sea level
- Time zone: America/Chicago (UTC -06:00); DST observed (UTC -05:00)
- Alternate names: Possum Town