Holdrege
- Country: United States
- State: Nebraska
- Population: 5,555 (2016)
- Latitude: 40° 26.4' N (40.44029°)
- Longitude: 99° 22.2' W (-99.36982°)
- Elevation: 711 m/2,333 ft. above sea level
- Time zone: America/Chicago (UTC -06:00); DST observed (UTC -05:00)
- Alternate names: Holdredge