Santo Domingo Pueblo
- Country: United States
- State: New Mexico
- Population: 2,456 (2010)
- Latitude: 35° 30.9' N (35.51476°)
- Longitude: 106° 22' W (-106.36586°)
- Elevation: 1,581 m/5,187 ft. above sea level
- Time zone: America/Denver (UTC -07:00); DST observed (UTC -06:00)
- Alternate names: Santo Domingo Pueblo CDP, Dji'wi, Kin Klekai Ni, Ki'wa, Quigui, Quiqui, Santo Domingo, Ta-wi-gi, Tawigi'i, Tewiai, Tewige, Tihua, Ti'wi, To'hajilo, Towi, Tqo Hajilo, Tu-a-wi-hol, Tuwii, Tuwita, Tu-wit-ha, T'wi'wi, Tye'wa, Wehl'hluwalla
