Sayre
- Country: United States
- State: Pennsylvania
- Population: 5,357 (2016)
- Latitude: 41° 58.7' N (41.97896°)
- Longitude: 76° 30.9' W (-76.5155°)
- Elevation: 235 m/770 ft. above sea level
- Time zone: America/New_York (UTC -05:00); DST observed (UTC -04:00)